nav1 6 Search Results


nav1 6  (Alomone Labs)
96
Alomone Labs nav1 6
Nav1 6, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
nav1 6 - by Bioz Stars, 2026-02
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scn8a  (OriGene)
90
OriGene scn8a
Scn8a, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human scn8a hnav1 6 expression  (OriGene)
90
OriGene human scn8a hnav1 6 expression
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Human Scn8a Hnav1 6 Expression, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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halo-nav1.6  (SignaGen)
90
SignaGen halo-nav1.6
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Halo Nav1.6, supplied by SignaGen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cd4-nav1.6-nluc construct  (Inserm Transfert)
90
Inserm Transfert cd4-nav1.6-nluc construct
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Cd4 Nav1.6 Nluc Construct, supplied by Inserm Transfert, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti-nav1.6  (Abnova)
90
Abnova mouse anti-nav1.6
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Mouse Anti Nav1.6, supplied by Abnova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti-nav1.6 - by Bioz Stars, 2026-02
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nav1.6 + leak model  (PhaseSpace Inc)
90
PhaseSpace Inc nav1.6 + leak model
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Nav1.6 + Leak Model, supplied by PhaseSpace Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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nav 1.6 gene  (Trudeau Institute Inc)
90
Trudeau Institute Inc nav 1.6 gene
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Nav 1.6 Gene, supplied by Trudeau Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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shrna directed against mouse nav1.6 channel  (Obio Technology Corp Ltd)
90
Obio Technology Corp Ltd shrna directed against mouse nav1.6 channel
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Shrna Directed Against Mouse Nav1.6 Channel, supplied by Obio Technology Corp Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti-nav1.6  (GeneTex)
90
GeneTex rabbit anti-nav1.6
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Rabbit Anti Nav1.6, supplied by GeneTex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cdna constructs for wild-type human nav1.6 channels (np_055006.1)  (Beijing Genomics Institute Shenzhen)
90
Beijing Genomics Institute Shenzhen cdna constructs for wild-type human nav1.6 channels (np_055006.1)
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Cdna Constructs For Wild Type Human Nav1.6 Channels (Np 055006.1), supplied by Beijing Genomics Institute Shenzhen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hippocampal sodium channel nav1.6  (Imoto Machinery Co)
90
Imoto Machinery Co hippocampal sodium channel nav1.6
Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 <t>mice.</t> <t>Nav1.6:</t> n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).
Hippocampal Sodium Channel Nav1.6, supplied by Imoto Machinery Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 mice. Nav1.6: n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).

Journal: Proceedings of the National Academy of Sciences of the United States of America

Article Title: Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS

doi: 10.1073/pnas.2113813119

Figure Lengend Snippet: Both I NaP and hyperexcitability induced by PR 20 are blocked by antibodies targeting Nav1.2, β1, and β4. ( A ) A percentage increase graph for changes in I NaP at −20 mV of cortical motor neurons by PR 20 treatment (100 nM, 20 min) in the presence of the control IgG or Nav antibodies as indicated. I NaP was evoked by a depolarizing voltage ramp (−60 to 0 mV, 60 mV/s). All data are mean ± SEM. IgG: n = 5 and 2 mice. Nav1.2: n = 7 and 4 mice. Nav1.6: n = 5 and 2 mice. β1: n = 5 and 2 mice. β2: n = 3 and 2 mice. β4: n = 6 and 3 mice. Numbers of cells/mice analyzed are shown in parentheses. NS indicates not significantly different. * P < 0.05 vs. cells with control IgG (Student’s t test); ** P < 0.01 vs. cells with control IgG (Student’s t test). ( B–G ) Effects PR 20 on AP firing in IgG-injected ( B ; n = 7 and 2 mice), anti-Nav1.2 antibody–injected ( C ; n = 5 and 2 mice), anti-Nav1.6 antibody–injected ( D ; n = 6 and 2 mice), anti-β1 antibody–injected ( E ; n = 5 and 3 mice), anti-β2 antibody–injected ( F ; n = 4 and 2 mice), and anti-β4 antibody–injected ( G ; n = 7 and 3 mice) motor neurons. ( Left ) Representative AP traces in response to 250-pA current injection (1-s duration) before (black) and after (red) PR 20 treatment (100 nM, 20 min). (Right) Averaged F-I curve (from +50 to +350 pA; 1-s, 50-pA increments) before (black) and after (red) PR 20 treatment (100 nM, 20 min). All data are mean ± SEM. * P < 0.05 vs. before PR 20 treatment in the same group (paired Student’s t test); ** P < 0.01 vs. before PR 20 treatment in the same group (paired Student’s t test); *** P < 0.001 vs. before PR 20 treatment in the same group (paired Student’s t test).

Article Snippet: Plasmid DNA for human SCN8A (hNav1.6) expression (pCMV6-AC-Myc-DDK) was purchased from ORIGENE.

Techniques: Injection

β4 is critical for the PR 20 -mediated modulation of Nav1.2 channels. ( A–J ) Effects of PR 20 peptide on I-V relationships of the hNav1.2 channel coexpressed with β1 and β2 ( A ), the hNav1.2 channel coexpressed with β1 and β4 ( B ), the hNav1.6 channel coexpressed with β1 and β2 ( C ), the hNav1.6 channel coexpressed with β1 and β4 ( D ), the hNav1.2 channel coexpressed with β1 ( E ), the hNav1.2 channel coexpressed with β2 ( F ), the hNav1.2 channel coexpressed with β4 ( G ), the hNav1.2 channel coexpressed with the β4 C58A mutant ( H ), the hNav1.2 channel coexpressed with the β1 and β4 C58A mutant ( I ), and the hNav1.5 channel coexpressed with β4 ( J ) in HEK-293T cells. Currents were elicited from a V h of −120 mV to test potentials ranging from −60 to +20 mV in 5-mV increments. Black circles indicate control; red circles indicate 150 s after PR 20 application. All data are mean ± SEM. * P < 0.05 vs. control in the same group (Student’s t test); ** P < 0.01 vs. control in the same group (Student’s t test). ( K ) Western blotting images showing the expression profiles of Nav1.2, β1, β2, and β4 in V1, M1, or hippocampus. Quantification of the band intensity was performed using ImageJ (NIH). One-way ANOVA was used to evaluate statistical significance. * P < 0.05; ** P < 0.01; *** P < 0.001. ( L ) Interactions between bath-applied GFP-linked PR 20 with a C-terminal HA tag (GFP:PR 20 -HA) and Nav subunits (Nav1.2, β1, β2, and β4) in visual or motor cortices were assessed by pull-down assay using HA magnetic beads. Hippo, hippocampus; MC, M1; VC, V1; HA, hemagglutinin; IP; immunoprecipitation; pA, pico ampere; pF, picofarad.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Article Title: Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS

doi: 10.1073/pnas.2113813119

Figure Lengend Snippet: β4 is critical for the PR 20 -mediated modulation of Nav1.2 channels. ( A–J ) Effects of PR 20 peptide on I-V relationships of the hNav1.2 channel coexpressed with β1 and β2 ( A ), the hNav1.2 channel coexpressed with β1 and β4 ( B ), the hNav1.6 channel coexpressed with β1 and β2 ( C ), the hNav1.6 channel coexpressed with β1 and β4 ( D ), the hNav1.2 channel coexpressed with β1 ( E ), the hNav1.2 channel coexpressed with β2 ( F ), the hNav1.2 channel coexpressed with β4 ( G ), the hNav1.2 channel coexpressed with the β4 C58A mutant ( H ), the hNav1.2 channel coexpressed with the β1 and β4 C58A mutant ( I ), and the hNav1.5 channel coexpressed with β4 ( J ) in HEK-293T cells. Currents were elicited from a V h of −120 mV to test potentials ranging from −60 to +20 mV in 5-mV increments. Black circles indicate control; red circles indicate 150 s after PR 20 application. All data are mean ± SEM. * P < 0.05 vs. control in the same group (Student’s t test); ** P < 0.01 vs. control in the same group (Student’s t test). ( K ) Western blotting images showing the expression profiles of Nav1.2, β1, β2, and β4 in V1, M1, or hippocampus. Quantification of the band intensity was performed using ImageJ (NIH). One-way ANOVA was used to evaluate statistical significance. * P < 0.05; ** P < 0.01; *** P < 0.001. ( L ) Interactions between bath-applied GFP-linked PR 20 with a C-terminal HA tag (GFP:PR 20 -HA) and Nav subunits (Nav1.2, β1, β2, and β4) in visual or motor cortices were assessed by pull-down assay using HA magnetic beads. Hippo, hippocampus; MC, M1; VC, V1; HA, hemagglutinin; IP; immunoprecipitation; pA, pico ampere; pF, picofarad.

Article Snippet: Plasmid DNA for human SCN8A (hNav1.6) expression (pCMV6-AC-Myc-DDK) was purchased from ORIGENE.

Techniques: Mutagenesis, Western Blot, Expressing, Pull Down Assay, Magnetic Beads, Immunoprecipitation